Subfertility Treatment

PGD

PGS

Psychosocial Support

Centre of Assisted Reproduction and Embryology
The University of Hong Kong - Queen Mary Hospital (HKU-QMH CARE)
香港大學瑪麗醫院輔助生育中心

PGD

PGD is a reproductive technology used to test for a specific genetic disease or chromosomal error on embryos before transfer into the womb. This avoids the parents from passing the genetic disease to the next generation. We have over 10-year experience in performing PGD and had the first successful PGD baby in Hong Kong back in 2002 for a chromosomal abnormality and in 2004 for alpha-thalassemia. Nowadays, we have performed PGD on over 30 genetic conditions and the list continues to expand. The ongoing pregnancy rate per transfer for PGD is ~ 50%. (Ongoing pregnancy: ultrasound examination shows a live fetus at 8-10 weeks of gestation.)

Additional fee for embryo Selection:
1. PGD : monogenetic workup ~$3,000-30,000, treatment ~$11,000-20,000
2. PGD : translocation treatment ~$15,000-34,000
* Biopsy fee ~$8,000-12,000

Is PGD for me?

You are eligible for PGD if:

  • You have family history of a genetic disease and
  • You and/or your partner is a carrier of a genetic condition
  • You or your partner with abnormal karyotype such as balanced translocation.
What does PGD involve?
  • In vitro fertilization by intracytoplasmic sperm injection (ICSI)
  • Embryo culture
  • Embryo biopsy: 1 cell will be removed from each good quality day 3 embryo (6-8cell) OR 3-5 cells from a blastocyst
  • Genetic test will be performed on the single cell / trophectoderm cells
    • For single gene disease, polymerase chain reaction (PCR) is performed
    • For translocation, array CGH or NGS is used to test for 24 chromosomes
    • number of chromosome can be checked at the same time using NGS in patients with single gene diseases

The genetic result will usually be available on day 5 when the embryos reach the blastocyst stage. Normal embryos can be transferred, if available.

If NGS is used, blastocysts will be frozen after biopsy. Genetically normal blastocyst will be replaced in subsequent cycles.

What is pre-PGD workup?

There is no off-shelf PGD.  Single gene genetic diseases vary among individuals, therefore, we have to tailor-made PGD tests for every individual couple. Blood will be taken from couple (and other family members, if necessary).  Pre-PGD workup will be carried out, which usually takes 1-3 months to complete, depending on the complexity of the genetic condition.

 

 

normal result
translocation result
biopsy