Subfertility Treatment

PGD

PGS

Psychosoical Support

normal result
Centre of Assisted Reproduction and Embryology
The University of Hong Kong - Queen Mary Hospital (HKU-QMH CARE)
香港大學瑪麗醫院輔助生育中心

PGS

PGS refer to the technology to screen for 24 chromosomes on embryos before transfer into the womb. It is known that in woman with advanced age over 70% of embryos are abnormal in the number of chromosomes (aneuploidy), which will result in failure in implantation, recurrent miscarriage or occasionally an abnormal pregnancy such as Down's syndrome. We acquired the platform of array CGH (array comparative genetic hybridization) in 2012 and achieved in the first baby born after PGS in Hong Kong. We switched to NGS in 2015 and combined it with PGD for monogenic diseases. The ongoing pregnancy rate per transfer for PGS is ~ 50%. (Ongoing pregnancy: ultrasound examination shows a live fetus at 8-10 weeks of gestation.)

Additional fee for embryo Selection:
1. PGS: treatment ~$15,000-20,000
* Biopsy fee ~$8,000-12,000

Who is eligible for PGS?
  • Advance maternal age >=38
  • Recurrent miscarriage
  • Previous repeated abnormal pregnancies
  • Repeated failure in IVF cycles
What does PGS involve?
  • In vitro fertilization by intracytoplasmic sperm injection (ICSI)
  • Embryo culture
  • Embryo biopsy: 3-5 cells from blastocysts
  • Each blastocyst will be frozen individually
  • NGS will be performed on these trophectoderm cells
  • Blastocysts with normal number of chromosomes will be replaced in subsequent cycles, if available

 

 

trisomy-21 female result