e-mail address:dwchan@hku.hk
Tel: (852)2819-9386
Fax: (852)2816-1947

Dr. David W. CHAN

BSc ; M.Phil (HK) ; Ph.D (Monash)
Research Assistant Professor
Hon. Assistant Professor

 

Research Interest:

  • Finding and characterizing novel oncogenes and tumor suppressor genes in human cancers.

  • Delineation cell signaling pathways associated with gynaecological malignancies e.g. Wnt, ERK and Hedgehog signaling pathways.

 
 

Selected publications

  1. Chan DW, Liu VW, To RM, Chiu PM, Lee WY, Yao KM, Cheung AN, Ngan HY. (2009) Overexpression of FOXG1 contributes to TGF-beta resistance through inhibition of p21(WAF1/CIP1) expression in ovarian cancer. Brit. J Cancer 101(8):1433-43
  2. Tse KY, Liu VW, Chan DW, Chiu PM, Tam KF, Chan KK, Liao XY, Cheung AN, Ngan HY. (2009) Epigenetic alteration of the metallothionein 1E gene in human endometrial carcinomas. Tumour Biol. 30(2):93-9.
  3. Yu SY, Chan DW, Liu VW, Ngan HY. (2009) Inhibition of cervical cancer cell growth through activation of upstream kinases of AMP-activated protein kinase. Tumour Biol. 30(2):80-5.
  4. Chan DW, Liu VW, Tsao GS, Yao KM, Furukawa T, Chan KK, Ngan HY. (2008) Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells. Carcinogenesis 29(9):1742-50
  5. Chan DW, Yu SYM, Chiu PM, Yao KM, Liu VWS, Cheung ANY and Ngan HYS (2008) Overexpression of FOXM1 transcription factor is associated with cervical cancer progression and pathogenesis. J. Pathol. 5(3):245-52.
  6. Chan DW, Lee JMF, Chan CY and Ng IOL (2008) Genetic and epigenetic inactivation of T-cadherin in human hepatocellular carcinoma cells. Int. J. Cancer 123(5):1043-52.
  7. Chan DW, Chan CY, Yam JWP, Ching YP and Ng IOL (2006) Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer. Gastroenterology 131: 1218-1227.Zhang PP*, Chan DW*, Zhu YY, Li J, Ng IOL, Wan D and Gu JR (2006) Identification of carboxypeptidase of glutamate like-B as a candidate suppressor in cell growth and metastasis in human hepatocellular carcinoma. Clin Cancer Res 12: 6617-6625. * co-first authorship.
  8. Chan DW and Ng IOL (2006) Knock down of hepatitis B virus X protein reduces the tumorigenicity of hepatocellular carcinoma cells. J Pathol. 208:372-380
  9. Chan D, Wilson T, Xu D, Cowdery H, Sanij E, Hertzog P, Kola I (2003) Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1. Br J Cancer. 88:137-145.
  10. Xu D, Wilson T, Chan D, Luca ED, Zhou J, Hertzog P, Kola I (2002) Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells. EMBO J 21:4081-4093.
  11. Ip WK, Lau YL, Chan SY, Mok CC, Chan D, Tong KK, Lau CS (2000) Mannose-binding lectin and rheumatoid arthritis in southern Chinese. Arthritis Rheum. 43:1679-1687
  12. Mok CC, Lanchbury JS, Chan DW, Lau CS (1998) Interleukin-10 promoter polymorphisms in Southern Chinese patients with Systematic Lupus Erythematosus. Arthritis Rheum. 41:1090-1095
  13. Chan DW, Liang RHS, Chan VNY, Kwong YL, Chan TK (1997) Detection of T-cell receptor delta gene rearrangement by clonal specific polymerase chain reaction. Leukemia. 11 (Suppl 3):281-284
  14. Chan DW, Liang RHS, Kwong YL, Chan VNY (1996) Detection of T-cell receptor delta gene rearrangement in T-cell malignancies by clonal specific polymerase chain reaction and its application to detect minimal residual disease. Am J Hematol. 52:171-177
  15. Chan DW, Liang RHS, Kwong YL (1996) Pattern of T-cell receptor delta gene rearrangement by Southern blotting and polymerase chain reaction technique in Hong Kong Chinese patients with non-T-cell hematological malignancies. Hematol Oncol. 14:57-66
  16. Kwong YL, Liang R, Chiu E, Chan DW, Chan TK (1995) Hairy cell leukemia: treatment results and association with secondary malignancy. Am J Hematol. 48:291
  17. Kwong YL, Chan DW, Liang RHS (1995) TAL/SIL1 recombination in T acute lymphoblastic leukemia and T lymphoblastic lymphoma. Cancer Genet Cytogenet. 85:159-160

RESEARCH GRANTS

  1. CRCG Seed Funding Programme for Basic research, 2009 (Principle Investigator) – “Functional characterization of GRB7 and its variant, GRB7v, in ovarian cancer”
  2. CRCG Seed Funding Programme for Basic research, 2008 (Principle Investigator)- “Functional characterization of AMPKg 2 in ovarian cancer”
  3. CRCG Seed Funding Programme for Basic research, 2008 (Co-Investigator) – “Investigation of the potential oncogenic role of forkhead box transcription factor FoxG1 in ovarian cancer”
  4. CRCG Seed Funding Programme for Basic research, 2007 (Co-Investigator) – “Potential interaction between Zic2 and Gli proteins in enhancing the oncogenic role of hedgehog signaling in cervical cancer”
  5. CRCG Small Project Funding Programme, 2007 (Principle Investigator) – “Characterization of the roles of Dual specificity MAPK phosphatase 3 (MKP3) in ovarian cancer”
  6. Research Fund for the Control of Infectious Diseases, 2006 (Co-Investigator) – “Characterization of the roles of hepatitis B virus X protein in liver cancer”