e-mail address: ccn0106@netvigator.com

Tel: (852)2819-9378
Fax: (852)2816-1947

Dr. CHIU Chi Ngong Philip

BSc ; M Phil ; Ph D (HK)
Research Assistant Professor

Research interest:

  1.  Role of glycodelin in fertilization and immunology

  2. Adrenomedullin and sperm functions

  3. Progesterone effects and mechanism on sperm functions

  4. Sperm-oocyte interaction

  5. Immune interactions at the maternal-fetal interface

    6.  
 

Abstracts

  1. Lee KF , Cheung WKL, Chung MK, Chiu PC, Yeung WSB, Ng EHY (2005) Proteomic profiling of the uterine flushing from natural and stimulated cycles during peri-implantation period. P.529. Society for the Study of Reproduction -38th Annual Meeting. 24-27 Jul, Quebec, Canada .
  2. Yeung WSB, Chiu PC, Lee KF , Seppala M, Koistinen R, Koistinen H (2005) Roles of glycodelin in modulating sperm functions. Symposium on Post-meiotic approaches to male contraception. 8-10 Jun, Hong Kong .

  3. Chiu PC, Koistinen R, Koistinen H, Seppala M, Lee CKF, Yeung WSB. (2004) The binding kinetics of Glycodelin-S from human seminal plasma to human spermatozoa. The 37th Annual Meeting of the Society for the Study of Reproduction, Aug 1-4, Vancouver , British Columbia , Canada
  4. Hong SJ, Chiu PC, Lee CKF , Tse JYM, Ho PC, Yeung WSB . (2004) A capillary-cumulus model to study the selection of sperm by cumulus oophorus. The Symposium on Reproductive Health, May 30, Macau .
  5. Chiu PC, Koistinen R, Koistinen H, Seppala M, Lee CKF, Yeung WSB. (2002) The carbohydrate moieties of ZIF-1 was critical for the functioning of the glycoprotein.  The 14th Annual Scientific Meeting, Hong Kong Society of Endocrinology, Metabolism and Reproduction, Nov 24, Hong Kong .
  6. Chiu PC, Koistinen R, Koistinen H, Seppala M, Lee CKF. (2002) An isoform of glycodelin from human follicular fluid.  The 7th Research Postgraduate Symposium, The University of Hong Kong , Dec 7, Hong Kong .
  7. Chiu PC, Koistinen R, Koistinen H, Seppala M, Lee CKF. (2002) The binding kinetics of zona-binding inhibitory factor-1 from human follicular fluid to human spermatozoa.  The 35th Annual Meeting of the Society for the Study of Reproduction, Jul 27-31, Baltimore , Maryland , USA .
  8. Yeung WSB, Chiu PC, Hong SJ, and Lee KF. (2002) Role of glycodelin-F in fertilization. The Global Chinese Conference on Reproductive Medicine. Dec 14-15, Hong Kong .
  9. Chiu PC, Lee KF, Yeung WSB. (2001) The effect of ZIF-1 from human follicular fluid on capacitation of human spermatozoa. OP79. The 9th World Congress of Gynecological Endocrinology, Dec 2-5, Hong Kong , China .
  10. Chiu PC, Lee KF, Yeung WSB. (2001) The role of carbohydrate moieties of ZIF-1 in inhibiting spermatozoa-zona pellucida binding. O9. The second international Huaxia Congress of Endocrinology, Dec 14-17, Hong Kong , China . Published in the Hong Kong Med. J. 7 (suppl. 2), 40. 
  11. Tse JYM, Chiu PC, Lee KF , Seppala M, Koistinen H, Koistinen R, Yao YQ, and Yeung WSB. (2001) The ontogeny of glycodelin in human ovarian follicles during folliculogenesis. RT35. The 9th World Congress of Gynecological Endocrinology. Dec 2-5, Hong Kong .
  12. Chiu PC, Yeung WSB, and Ho P.C. (1999) Receptors for spermatozoa-zona binding inhibitory factors (ZIFs) of human follicular fluid in human spermatozoa The 4th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong.

 

Selected publications

  1. Chiu PC, Wong BS, Lee CL, Pang RT, Lee KF, Sumitro SB, Gupta SK and Yeung WSB (2008). Native human zona pellucida glycoproteins: Purification and binding properties. Hum. Reprod. (Epub ahead of print)
  2. Seppala M, Koistinen H, Koistinen R, Chiu PC and Yeung WSB (2007). Glycosylation related actions of glycodelin: gametes, cumulus cells, immune cells and clinical associations. Hum. Reprod. Update. 13(3):275-87
  3. Yeung WSB, Lee KF, Koistinen R, Hoistinen H, Seppala M, Ho PC and Chiu PC (2007). Glycodelin: a molecule with multi-functions on spermatozoa. Soc Reprod Fertil Suppl. 63:143-51.
  4. Chiu PC, Chung MK, Koistinen R, Koistinen H, Seppala M, Ho PC, Ng EH, Lee KF and Yeung WSB (2007). Cumulus oophorus-associated glycodelin-C displaces sperm bound glycodelin-A and –F and stimulates spermatozoa-zona pellucida binding. J. Biol. Chem. 282(8):5378-5388.
  5. Chiu PC, Chung MK, Koistinen R, Koistinen H, Seppala M, Ho PC, Ng EH, Lee KF and Yeung WSB (2007). Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding. J. Cell Sci. 120(Pt 1):33-44.
  6. Yeung WSB, Lee KF, Koistinen R, Hoistinen H, Seppala M, Ho PC and Chiu PC (2006). Roles of glycodelin in modulating sperm function. Mol. and Cell. Endocrinol. 250(1-2):149-56.
  7. Chiu PC, Chung MK, Tsang HY, Koistinen R, Koistinen H, Seppala M, Lee KF and Yeung WSB (2005). Glycodelin-S in human seminal plasma reduces cholesterol efflux and inhibits capacitation of spermatozoa. J. Biol. Chem. 280(27):25580-9.
  8. Hong SJ, Chiu PC, Lee KF, Tse JM, Ho PC and Yeung WSB (2004). Establishment of a capillary-cumulus model to study the selection of sperm for fertilization by the cumulus oophorus. Hum. Reprod. 19(7):1562-9.
  9. Chiu PC, Tsang HY, Koistinen R, Koistinen H, Seppala M, Lee KF and Yeung WSB (2004). The contribution of D-mannose, L-fucose, N-acetylglucosamine and selectin residues on the binding of glycodelin isoforms to human spermatozoa. Biol. Reprod. 70(6):1710-9.
  10. Chiu PC, Koistinen R, Koistinen H, Seppala M, Lee KF and Yeung WSB (2003). Zona-binding inhibitory factor-1 from human follicular fluid is an isoform of glycodelin. Biol. Reprod. 69(1):365-72.
  11. Koistinen H, Easton RL, Chiu PC, Chalabi S, Halttunen M, Dell A, Morris HR and Yeung WSB, Seppala M, Koistinen R (2003). Differences in glycosylation and sperm-egg binding inhibition of pregnancy-related glycodelin. Biol. Reprod. 69(5):1545-51.
  12. Chiu PC, Koistinen R, Koistinen H, Seppala M, Lee KF and Yeung WSB (2003). Binding of zona binding inhibitory factor-1 (ZIF-1) from human follicular fluid on spermatozoa. J. Biol. Chem. 278(15):13570-7.
  13. Chiu PC, Ho PC, Ng EH and Yeung WSB (2003). Comparative study of the biological activity of spermatozoa-zona pellucida binding inhibitory factors from human follicular fluid on various sperm function parameters. Mol. Reprod. Dev. 61(2):205-12.
  14. Tse JY, Chiu PC, Lee KF, Seppala M, Koistinen H, Koistinen R, Yao YQ and Yeung WSB (2002). The synthesis and fate of glycodelin in human ovary during folliculogenesis. Mol Hum. Reprod. 8(2):142-8.
  15. Yeung WS, Chiu PC, Wang CH, Yao YQ and Ho PC (2002). The effects of levonorgestrel on various sperm functions. Contraception 66(6):453-7.
  16. Yao YQ, Chiu PC, Ip SM, Ho PC and Yeung WSB (1998). Glycoproteins present in human follicular fluid that inhibit the zona-binding capacity of spermatozoa. Hum. Reprod. 13(9):2541-7.

 

BOOK CHAPTER

Seppala M, Koistinen R, Koistinen H, Chiu PC and Yeung WSB. Glycodelin:A Lipocalin with Diverse Glycoform-Dependent Actions, Lipocalins, 2006, Akerström B, N. Borregaard, D.R. Flower Edward, J.P. Salier, Landes Bioscience, 121-130.

 

GRANTS

Identification of ZP protein receptors in human spermatozoa. Seed Funding Programme for Basic Research (Principal-Investigator). HK$ 120,000 (2007-2008)

The Mechanism of action of a novel glycodelin isoform from cumulus matrix on stimulating spermatozoa-zona pellucida binding. University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) Earmarked Grant for Research 2006-2007 (Co-Investigator) HK$1,279,500 (2006-2009)

Adrenomedullin and sperm functions. University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) Earmarked Grant for Research 2006-2007 (Co-Investigator) HK$654,500 (2006-2009)

Glycodelin-A binds to and protects human spermatozoa from T-lymphocyte attack. Small Project Funding 2006-2007 (Co-Investigator) HK$ 78,248 (2005-2007)

The mechanisms of action of glycodelin-A on zona pellucida induced acrosome reaction. Small Project Funding 2005-2006 (Co-Investigator) HK$ 66,150 (2005-2007)

PATENT

Fucosyltransferase-5 as zona pellucida protein receptor on human sperm–IP00226
Yeung WSB, Chiu PC and Lee KF (provisional application submitted)