e-mail address: thyl@hkucc.hku.hk
Tel: (852)2819-9368
Fax: (852)2816-1947

Dr. Leung Ho Yin Thomas

BSc (HKUST), MPhil (CUHK), PhD (HKU)
Postdoctoral Fellow

 

Research Interest:

  • Cell signaling pathways in human cancers
  • Identifying and characterizing new genes in cervical cancer

 
 

Selected publications

  1. Leung TH, Yam JW, Ng IO. STARD13 (StAR-related lipid transfer (START) domain containing 13). Atlas Genet Cytogenet Oncol Haematol. November 2007
  2. Yam JW, Ko FC, Chan CY, Yau TO, Tung EK, Leung TH, Jin DY, Ng IO. Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma. Hepatology. 2006 Oct;44(4):881-90.
  3. Leung TH, Ching YP, Yam JW, Wong CM, Yau TO, Jin DY, Ng IO. Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity. Proc Natl Acad Sci U S A 2005 Oct 18; 102(42): 15207-12.
  4. Wong CM, Yam JW, Ching YP, Yau TO, Leung TH, Jin DY, Ng IO. Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma. Cancer Res. 2005 Oct 1; 65(19): 8861-8.
  5. Leung TH, Ching YP, Wong CM, Ng DC, Jin DY, Ng IO. Identification of multiple isoforms of DLC2, a novel tumor suppressor gene, and their functional characterization in hepatocellular carcinoma. Asian Journal of Surgery. 2005 Jan, 28(1): 83.
  6. Ching YP, Wong CM, Chan SF, Leung TH, Ng DC, Jin DY, Ng IO. Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. J Biol Chem. 2003 Mar 21; 278(12):10824-30.
  7. Leung TH, Wong N, Lai PB, Chan A, To KF, Liew CT, Lau WY, Johnson PJ. Identification of four distinct regions of allelic imbalances on chromosome 1 by the combined comparative genomic hybridization and microsatellite analysis on hepatocellular carcinoma. Mod Pathol. 2002 Nov; 15(11):1213-20.

 

Grants and Patents:

  1. Seed Funding Programme for Basic Research (HKU) (Co-Investigator)
    Amount awarded: $106,000
    Differential expression of DeltaNp73 controlling the radiotherapeutic response in cervical cancers
  2. Small Project Funding (HKU) (Principle Investigator)
    Amount awarded: $80,000
    Functional characterization of DLC 2 in suppression of cancer cell growth and tumorigenicity in liver cancer