e-mail address: stephas1@hkusua.hku.hk
Tel: (852)2819-9375
Fax: (852)2816-1947

Dr. LIU Si, Stephanie

MD (China) ; M Sc (Canada) ; Ph.D (HK)
Research Officer

Research interest:

1)  Functional and epigenetic study of oncogenes and tumor suppressor genes (involved in apoptotic pathway) in response to radio and chemotherapies in gynecological tumors.

2)  Genetic epidemiological study including human papillomavirus (HPV) infection in cervical precancerous lesions and carcinomas, risk association study of single nucleotide polymorphisms (SNPs) of oncogenes and tumor suppressor genes in gynecological tumors.

 
 

Selected Publications

  1. Chan KK, Wei N, Liu SS, Xiao-Yun L, Cheung AN, Ngan HY: Estrogen receptor subtypes in ovarian cancer: a clinical correlation. Obstet Gynecol 2008;111:144-151.
  2. Tam KF, Liu VW, Liu SS, Tsang PC, Cheung AN, Yip AM, Ngan HY: Methylation profile in benign, borderline and malignant ovarian tumors. J Cancer Res Clin Oncol 2007;133:331-341.
  3. Liu SS, Chan KY, Cheung AN, Liao XY, Leung TW, Ngan HY: Expression of deltaNp73 and TAp73alpha independently associated with radiosensitivities and prognoses in cervical squamous cell carcinoma. Clin Cancer Res 2006;12:3922-3927.
  4. Liu SS, Chan KY, Leung RC, Law HK, Leung TW, Ngan HY: Enhancement of the radiosensitivity of cervical cancer cells by overexpressing p73alpha. Mol Cancer Ther 2006;5:1209-1215.
  5. Tam KF, Ng TY, Liu SS, Tsang PC, Kwong PW, Ngan HY: Potential application of the ATP cell viability assay in the measurement of intrinsic radiosensitivity in cervical cancer. Gynecol Oncol 2005;96:765-770.
  6. Liu SS, Leung RC, Chan KY, Chiu PM, Cheung AN, Tam KF, Ng TY, Wong LC, Ngan HY: p73 expression is associated with the cellular radiosensitivity in cervical cancer after radiotherapy. Clin Cancer Res 2004;10:3309-3316.
  7. Chen CL, Liu SS, Ip SM, Wong LC, Ng TY, Ngan HY: E-cadherin expression is silenced by DNA methylation in cervical cancer cell lines and tumours. Eur J Cancer 2003;39:517-523.
  8. Liu SS, Cheung AN, Ngan HY: Differential gene expression in cervical cancer cell lines before and after ionizing radiation. Int J Oncol 2003;22:1091-1099.
  9. Ngan HY, Cheung AN, Liu SS, Liu KL, Tsao SW: Telomerase assay and HPV 16/18 typing as adjunct to conventional cytological cervical cancer screening. Tumour Biol 2002;23:87-92.
  10. Liu SS, Tsang BK, Cheung AN, Xue WC, Cheng DK, Ng TY, Wong LC, Ngan HY:      Anti-apoptotic proteins, apoptotic and proliferative parameters and their prognostic significance in cervical carcinoma. Eur J Cancer 2001;37:1104-1110.
  11. Ngan HY, Cheung AN, Liu SS, Cheng DK, Ng TY, Wong LC: Abnormal expression of pan-ras, c-myc and tp53 in squamous cell carcinoma of cervix: correlation with HPV and prognosis. Oncol Rep 2001;8:557-561.
  12. Ngan HY, Cheung AN, Liu SS, Cheng DK, Ng TY, Wong LC: Abnormal expression of epidermal growth factor receptor and c-erbB2 in squamous cell carcinoma of the cervix: correlation with human papillomavirus and prognosis. Tumour Biol 2001;22:176-183.
  13. Ngan HY, Liu VW, Liu SS, Cheng DK, Ng TY, Wong LC: Homozygous arginine at codon 72 of p53 has no prognostic significance in cervical cancer. Tumour Biol 2000;21:135-138.
  14. Ngan HY, Liu SS, Yu H, Liu KL, Cheung AN: Proto-oncogenes and p53 protein expression in normal cervical stratified squamous epithelium and cervical intra-epithelial neoplasia. Eur J Cancer 1999;35:1546-1550.
  15. Ngan HY, Liu VW, Liu SS: Risk of cervical cancer is not increased in Chinese carrying homozygous arginine at codon 72 of p53. Br J Cancer 1999;80:1828-1829.
  16. Ngan HY, Cheung AN, Liu SS, Yip PS, Tsao SW: Abnormal expression or mutation of TP53 and HPV in vulvar cancer. Eur J Cancer 1999;35:481-484.
  17. Zhang DK, Ngan HY, Cheng RY, Cheung AN, Liu SS, Tsao SW: Clinical significance of telomerase activation and telomeric restriction fragment (TRF) in cervical cancer. Eur J Cancer 1999;35:154-160.
  18. He D, Zhang DK, Lam KY, Ma L, Ngan HY, Liu SS, Tsao SW: Prevalence of HPV infection in esophageal squamous cell carcinoma in Chinese patients and its relationship to the p53 gene mutation. Int J Cancer 1997;72:959-964.
  19. Ngan HY, Tsao SW, Liu SS, Stanley M: Abnormal expression and mutation of p53 in cervical cancer--a study at protein, RNA and DNA levels. Genitourin Med 1997;73:54-58
  20. Ngan HY, Stanley M, Liu SS, Ma HK: HPV and p53 in cervical cancer. Genitourin Med 1994;70:167-170.