e-mail address: vwsliu@hkusua.hku.hk
Tel:(852)2819-9367
Fax:(852)2816-1947

Dr. LIU Vincent Wing Sun

Ph.D. in Biochemistry and Molecular Biology, Monash University, Australia
Research Assistant Professor

 

Research Interest:

  • Molecular biology of the mitochondrial genome in gynaecological cancer
  • Gene expression profiling in gynaecological cancer
  • Cancer cell growth under stresses such as hypoxia and nutrient deprivation

 
 

Selected publications

  1. Wang Y., Liu V.W.S., Tsang P.C.K., Chiu P.M., Cheung A.N.Y., Khoo U.S., Nagley P. & Ngan H.Y.S. Microsatellite instability in mitochondrial genome of common female cancers. International Journal of Gynecologic Cancers (in press).
  2. Wang Y, Liu V.W.S., Ngan HY, Nagley P. Frequent occurrence of mitochondrial microsatellite instability in the d-loop region of human cancers. Ann N Y Acad Sci. 2005;1042:123-129.
  3. Wang Y, Liu V.W.S., Xue WC, Tsang PC, Cheung AN, Ngan HY. The increase of mitochondrial DNA content in endometrial adenocarcinoma cells: A quantitative study using laser-captured microdissected tissues. Gynecol Oncol. 2005;98:104-110.
  4. Yang HJ, Liu V.W.S., Tsang PC, Yip AM, Tam KF, Wong LC, Ng TY, Ngan HY. Quantification of human papillomavirus DNA in the plasma of patients with cervical cancer. Int J Gynecol Cancer. 2004;14:903-10.
  5. Yang HJ, Liu V.W.S., Wang Y, Chan KY, Tsang PC, Khoo US, Cheung AN, Ngan HY. Detection of hypermethylated genes in tumor and plasma of cervical cancer patients. Gynecol Oncol. 2004;93:435-40.
  6. Yang HJ, Liu V.W.S., Tsang PC, Yip AM, Ng TY, Cheung AN, Ngan HY. Comparison of human papillomavirus DNA levels in gynecological cancers: implication for cancer development. Tumour Biol. 2003;24:310-6.
  7. Liu V.W.S., Yang HJ, Wang Y, Tsang PC, Cheung AN, Chiu PM, Ng TY, Wong LC, Nagley P, Ngan HY. High frequency of mitochondrial genome instability in human endometrial carcinomas. Br J Cancer. 2003;89:697-701.
  8. Chiu PM, Liu V.W.S., Ngan HY, Khoo US, Cheung AN. Detection of mitochondrial DNA mutations in gestational trophoblastic disease. Hum Mutat. 2003;22:177.
  9. Liu V.W.S., Wang Y, Yang HJ, Tsang PC, Ng TY, Wong LC, Nagley P, Ngan HY. Mitochondrial DNA variant 16189T>C is associated with susceptibility to endometrial cancer. Hum Mutat. 2003;22:173-4.
  10. Liu V.W.S., Shi HH, Cheung AN, Chiu PM, Leung TW, Nagley P, Wong LC, Ngan HY. High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas. Cancer Res. 2001;61:5998-6001.
  11. Shen, D.H., Khoo, U.S., Xue, W.C., Ngan, H.Y.S., Wang, J.L., Liu, V.W.S., Chan, Y.K., and Cheung, A.N.Y. Primary peritoneal malignant mixed Mullerian tumors. A clinicopathologic, immunohistochemical, and genetic study. Cancer 2001;91: 1052-1060.
  12. Liu, V.W.S., Tsang, P., Yip, A., Ng, T.Y., Wong L.C., and Ngan H.Y.S. Low incidence of HPV DNA in serum of cervical cancer patients. Gynecologic Oncology, 2001;82: 269-272.
  13. Liu V.W.S., Nagley P, Ngan HY. One-step directional cloning of blunt-ended polymerase chain reaction products. Anal Biochem. 2000;287:349-52.
  14. Ngan HY, Liu V.W.S., Liu SS, Cheng DK, Ng TY, Wong LC. Homozygous arginine at codon 72 of p53 has no prognostic significance in cervical cancer. Tumour Biol. 2000;21:135-8.
  15. Ngan HY, Liu V.W.S., Liu SS. Risk of cervical cancer is not increased in Chinese carrying homozygous arginine at codon 72 of p53. Br J Cancer. 1999;80:1828-9.