E-mail: wsbyeung@hkucc.hku.hk

Tel:(852)2255-3405;
Fax:(852)2817-5374;
(852)2855-0947

Department of Obstetrics and Gynaecology,
Rm 532, 5/F, Block K, Pokfulam Road, Queen Mary Hospital

YEUNG Shu-Biu William
B Sc (HK) ; Ph D (HK)
Professor

 

Research Interest

    • Interaction between sperm/embryo with female reproductive tract
    • Biological function of glycodelins
    • Fertilization
    • MicroRNAs and reproduction

 

 

 Recent Selected Publications

  1. Chiu PCN, Koistinen R, Koistinen H, Seppala M, Lee KF, Yeung WSB (2003) Binding of zona binding inhibitory factor-1 (ZIF-1) from human follicular fluid on the human spermatozoa. Journal of Biological Chemistry 278(15):13570-7.

  2. Lee YL, Lee KF, Xu JS, He QY, Chiu JF, Lee WM, Luk JM, Yeung WSB (2004) The embryotrophic activity of oviductal cell derived complement C3b and iC3b – a novel function of complement protein in reproduction.  Journal of Biological Chemistry 279(13):12763-8.

  3. Chiu PCN, Tsang HY, Chung MK, Koistinen R, Koistinen H, Seppala M, Lee KF, Yeung WSB (2005) Glycodelin-S in human seminal plasma reduces cholesterol efflux and inhibits capacitation of spermatozoa. Journal of Biological Chemistry 280(27):25580-25589.

  4. Yeung WSB, Lee KF, Riitta Koistinen, Hannu Koistinen, Markku Seppala, P.C. Ho Chiu PCN (2006) Roles of Glycodelin in Modulating Sperm Functions.  Molecular Cellular Endocrinology 250, 149-156

  5. Chiu PCN, Chung MK, Koistinen R, Koistinen H, Seppala M, Lee KF, Ho PC, Ng EHY, Yeung WSB (2007) Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding. Journal of Cell Science 120(Pt 1):33-44

  6. Chiu PCN, Chung MK, Koistinen R, Koistinen H, Seppala M, Lee KF, Ho PC, Ng EHY, Yeung WSB (2007) Cumulus oophorus-associated glycodelin-C displaces sperm bound glycodelin-A and –F and stimulates spermatozoa-zona pellucida binding. Journal of Biological Chemistry 282(8):5378-5388.

  7. Tse PK, Lee YL, Chow WN, Luk JM, Lee KF, Yeung WSB (2008) Preimplantation embryo cooperates with oviductal cells to produce embryotrophic iC3b. Endocrinology 149(3):1268-76.

  8. Chiu PCN, Wong BS, Lee CL, Pang RT, Lee KF, Sumitro SB, Gupta SK, Yeung WSB (2008). Native human zona pellucida glycoproteins: purification and binding properties Human Reproduction 23(6):1385-93

  9. Chiu PC, Wong BS, Chung MK, Lam KK, Pang RT, Lee KF, Sumitro SB, Gupta SK, Yeung WSB (2008) Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa. Biology of Reproduction 79(5):869-77

  10. Lee CL, Pang PC, Yeung WSB, Tissot B, Panico M, Lao TT, Chu IK, Lee KF, Chung MK, Lam KK, Koistinen R, Koistinen H, Seppälä M, Morris HR, Dell A, Chiu PC (2009) Effects of differential glycosylation of glycodelins on lymphocyte survival. Journal of Biological Chemistry 284(22):15084-96.

Selected grants

  1. Yeung WSB (P.I.), Chiu PCN, Lee CKF (2006-2009) The mechanism of action of a novel glycodelin isoform from cumulus matrix on stimulating spermatozoa-zona pellucida binding (HKU 7647/06M)

  2. Lee CKF (P.I.) Liu YX (P.I.) Yeung WSB, Gao F (2007-2010) Functional characterization of a testis-specific TRS4 gene on spermatogenesis by tissue-specific conditional inactivation (N_HKU 712/06)

  3. Yeung WSB (P.I.) Lee CKF, Pang RTK (2009-2010) A study on glycodelin-A induced differentiation of trophoblast cells (HKU780308)

  4. Chiu PCN (P.I.), Lao TTH, Pang RTK, Yeung WSB (2009-2010) Control of human trophoblast invasion by glycodelin-A (HKU 763508M)

  5. Yeung WSB (P.I.), Chan RWS, Lee CKF, Luk JM, Ng EHY (2010-2012) Characterization of stem/progenitor cells in human endometriosis (HKU 782209M)