- Interaction between sperm/embryo with female reproductive tract
- Function of glycodelins
- MicroRNAs and reproduction
- Endometrial stem cells
Auther Name: Yeung WS
Chow, J., Cheng, H., Lau, E., Yeung, W., & Ng, E. (2020). Distinguishing between carrier and noncarrier embryos with the use of long-read sequencing in preimplantation genetic testing for reciprocal translocations. Genomics, 112(1), 494-500
- Chen C.H., PENG Q., Fong S.W., Yeung W.S.B. and Lee C.Y.L., Sirt1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming, Aging. 2020. http://dx.doi.org/10.18632/aging.103090
- Hautala LC, Pang PC, Antonopoulos A, Pasanen A, Lee CL, Chiu PCN, Yeung WSB, Loukovaara M, Bützow R, Haslam SM, Dell A, Koistinen H. Altered glycosylation of glycodelin in endometrial carcinoma. Laboratory Investigation.
- Wang X, Lee CL (Co-first author), Vijayan M, Yeung WSB, Ng EHY, Wang X, Li HWR, Zhang Y, Chiu PCN. Adrenomedullin insufficiency alters macrophage activities in pro-inflammatory conditions: a pathophysiologic explanation of tubal ectopic pregnancy. Mucosal Immunology.
Chow, J., Cheng, H., Lau, E., Yeung, W., & Ng, E. (2019). Selective transfer of euploid noncarrier embryos with the use of long-read sequencing in preimplantation genetic testing for reciprocal translocation. Reproductive BioMedicine Online, 39, E14-E15
Gao X, Nowak-Imialek M, Chen X, Chen D, Herrmann D, Ruan D, Chen ACH, Eckersley-Maslin MA, Ahmad S, Lee YL, Kobayashi T, Ryan D, Zhong J, Zhu J, Wu J, Lan G, Petkov S, Yang J, Antunes L, Campos LS, Fu B, Wang S, Yong Y, Wang X, Xue SG, Ge L, Liu Z, Huang Y, Nie T, Li P, Wu D, Pei D, Zhang Y, Lu L, Yang F, Kimber SJ, Reik W, Zou X, Shang Z, Lai L, Surani A, Tam PPL, Ahmed A, Yeung WSB, Teichmann SA, Niemann H, and Liu P (2019). Establishment of porcine and human expanded potential stem cells. Nature Cell Biology. 21(6): p. 687-699
- Cao M, Chan RWS, Cheng FHC, Xua S, Li J, Li T, Pang RTK, Lee CL, Li RHW, Ng EHY, Chiu PCN, Yeung WSB. Myometrial cells stimulate self-renewal of endometrial mesenchymal stem-like cells through WNT5A/β-catenin signaling. Stem cells. 2019. 37(11):1455–1466.
- Mei S, Chen P, Lee CL, Zhao W, Wang Y, Lam KKW, Ho PC, Yeung WSB, Fang C, Chiu PCN. The role of galectin-3 in spermatozoa-zona pellucida binding and its association with fertilization in vitro. Molecular Human Reproduction. 2019. 25(8):458-470.
KUBI J.A., Chen C.H., Fong S.W., Lai K.P., Wong C.K.C., Yeung W.S.B., Lee C.K.F. and Lee C.Y.L., Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the differentiation of embryonic stem cells towards pancreatic lineage and pancreatic beta cell function, Environment International. 2019, 130, 104885. http://dx.doi.org/10.1016/j.envint.2019.05.079
Lee C.L., Vijayan M., Wang X., Lam K.W., Koistinen H., Seppala M., Li R.H.W., Ng E.H.Y., Yeung W.S.B. and Chiu C.N., Glycodelin-A stimulates the conversion of human peripheral blood CD16−CD56bright NK cell to a decidual NK cell-like phenotype, Human Reproduction. 2019, 34, 689-701. http://dx.doi.org/10.1093/humrep/dey378
Li R.H.W., Ko K.Y.J., Lee V.C.Y., Yung S.F.S., Lau Y.L.E., Yeung W.S.B., Ho P.C. and Ng E.H.Y., Comparing antral follicle count and serum anti?Mullerian hormone level for determination of gonadotrophin dosing in in?vitro fertilisation: a randomized trial , Ultrasound in Obstetrics & Gynecology. 2019. http://dx.doi.org/10.1002/uog.20402
Lui M.W.E., Yeung W.S.B., Ho P.C. and Ng E.H.Y., In vitro fertilisation in Hong Kong: the situation in 2019, Hong Kong Medical Journal. 2019. http://dx.doi.org/10.12809/hkmj198057
Wang X., Lee C.L., Li R.H.W., Vijayan M., Duan Y., Yeung W.S.B., Zhang Y.Z. and Chiu C.N., Alteration of the immune cell profiles in the pathophysiology of tubal ectopic pregnancy, American Journal of Reproductive Immunology. 2019, 81, e13093. http://dx.doi.org/10.1111/aji.13093
Lai K.P., Li J.W., Chan T.F., Chen C.H., Lee C.Y.L., Yeung W.S.B. and Wong C.K., Transcriptomic and methylomic analysis reveal the toxicological effect of 2,3,7,8-Tetrachlorodibenzodioxin on human embryonic stem cell. , Chemosphere. Elsevier Ltd, 2018, 206, 663-673. http://dx.doi.org/10.1016/j.chemosphere.2018.05.058
Chow JF, Yeung WS, Lee VC, Lau EY, Ng EH. Evaluation of preimplantation genetic testing for chromosomal structural rearrangement by a commonly used next generation sequencing workflow. Eur J Obstet Gynecol Reprod Biol. 2018 May;224:66-73.
Chow J.F.C., Yeung W.S.B., Lee V.C.Y., Lau Y.L.E. and Ng E.H.Y., Evaluation of preimplantation genetic testing for chromosomal structural rearrangement by a commonly used next generation sequencing workflow, European Journal of Obstetrics & Gynecology and Reproductive Biology. 2018, 224: 66-73. http://dx.doi.org/10.1016/j.ejogrb.2018.03.013 (Publication No. : 293617)
Lai K.P., Li J.W., Chan T.F., Chen C.H., Lee C.Y.L., Yeung W.S.B. and Wong C.K., Transcriptomic and methylomic analysis reveal the toxicological effect of 2,3,7,8-Tetrachlorodibenzodioxin on human embryonic stem cell. , Chemosphere. Elsevier Ltd, 2018, 206: 663-673. http://dx.doi.org/10.1016/j.chemosphere.2018.05.058 (Publication No. : 295250)
Lai S.F., Li R.H.W., Yeung W.S.B. and Ng E.H.Y., Effect of paternal age on semen parameters and live birth rate of in-vitro fertilisation treatment: a retrospective analysis, Hong Kong Medical Journal. 2018. http://dx.doi.org/10.12809/hkmj177111 (Publication No. : 295766)
Peng Q./., YUE C., Chen C.H., Lee K.C., Fong S.W., Yeung W.S.B. and Lee C.Y.L., Connexin 43 is involved in early differentiation of human embryonic stem cells, Differentiation. 2018, 105, 33-44. http://dx.doi.org/10.1016/j.diff.2018.12.003
Wong H.Y.Q., Li R.H.W., Lam K.S.L., Tam S., Shek C.C., Lee V.C.Y., Yeung W.S.B., Ho P.C. and Ng E.H.Y., Independent association of serum vitamin D with anti-Mullerian hormone levels in women with polycystic ovary syndrome, Clinical Endocrinology. 2018. http://dx.doi.org/10.1111/cen.13816 (Publication No. : 293219)
Chan RWS, Lee CL, Ng EH, Yeung WSB. Coculture with Macrophages enhanced the Clonogenic and Invasion Activity of Endometriotic Stromal Cells. Cell Proliferation. 2017;50:e12330.
Chan R.W.S., Lee C.L., Ng E.H.Y. and Yeung W.S.B., Co-culture with macrophages enhances the clonogenic and invasion activity of endometriotic stromal cells, Cell Proliferation. John Wiley & Sons Ltd, 2017, 50: 1-9.
Chen C.H., Lee C.Y.L., Fong S.W., Wong C.C.Y., Ng E.H.Y. and Yeung W.S.B., Hyperglycemia impedes definitive endoderm differentiation of human embryonic stem cells by modulating histone methylation patterns, Cell and Tissue Research. 2017, 2017 Jun;368(3):563-578.
Chen C.H., Lee C.Y.L., Fong S.W., Wong C.C.Y., Ng E.H.Y. and Yeung W.S.B., Hyperglycemia impedes definitive endoderm differentiation of human embryonic stem cells by modulating histone methylation patterns, Cell and Tissue Research. 2017, 2017 Jun;368(3):563-578.
Chow JF, Yeung WS, Lee VC, lau EY, Ho PC, Ng EH. Preimplantation genetic diagnosis and screening by array comparative genomic hybridisation: experience of more than 100 cases in a single centre. Hong Kong Med J. 2017 Apr;23(2):129-33.
Lee VCY, Chow JFC, Yeung WSB, Ho PC. Preimplantation genetic diagnosis for monogenic diseases. Best Pract Res Clin Obstet Gynaecol. 2017 Oct;44:68-75.
Lee VCY, Li RHW, Yeung WSB, Pak Chung HO, Ng EHY. A randomized double-blinded controlled trial of hCG as luteal phase support in natural cycle frozen embryo transfer. Hum Reprod. 2017 May 1;32(5):1130-1137.
Li HWR, Li YX, Li TT, Fan H, Ng EH, Yeung WS, Ho PC, Lee KF. Effect of ulipristal acetate and mifepristone at emergency contraception dose on the embryo-endometrial attachment using an in vitro human trophoblastic spheroid and endometrial cell co-culture model. Hum Reprod. 2017 Dec 1;32(12):2414-2422. doi: 10.1093/humrep/dex328.
Wong C.W., Lam K.W., Lee C.L., Yeung W.S.B., Zhao W.E., Ho P.C., Oue J.P. and Chiu C.N., The roles of protein disulphide isomerase family A, member 3 (ERp57) and surface thiol/disulphide exchange in human spermatozoa-zona pellucida binding, Human Reproduction. 2017, 32: 733-742.
Xu S., Chan R.W.S., Ng E.H.Y. and Yeung W.S.B., Spatial and temporal characterization of endometrial mesenchymal stem-like cells activity during the menstrual cycle, Experimental Cell Research. Elsevier Inc, 2017, 350(1): 184-189.
Ko K.Y.J., Chai J., Lee V.C.Y., Li R.H.W., Lau Y.L.E., Ho K.L., Tam P.C., Yeung W.S.B., Ho P.C. and Ng E.H.Y., Sperm retrieval rate and pregnancy rate in infertile couples undergoing in-vitro fertilisation and testicular sperm extraction for non-obstructive azoospermia in Hong Kong, Hong Kong Medical Journal. 2016, 22(6): 556-562.
Lee C.L., Lam K.K., VIJAYAN M., Koistinen H., Seppala M., Ng E.H.Y., Yeung W.S.B. and Chiu C.N., The pleiotropic effect of glycodelin-A in early pregnancy, American Journal of Reproductive Immunology. 2016, 75(3): 290-297.
Lee VC, Chow JF, Lau EY, Kwong A, Leung SY, Yeung WS, Ho PC, Ng EH. 2016 Preimplantation genetic diagnosis for hereditary cancer syndrome: local experience. Hong Kong Med J. Jun; 22(3): 289-91.
Liu W., NIU Z., LI Q., Pang T.K.R., Chiu C.N. and Yeung W.S.B., MicroRNA and Embryo Implantation, American Journal of Reproductive Immunology. 2016, 75: 263-271.
Yung SS, Lee VC, Chiu PC, Li HW, Ng EH, Yeung WS, Ho PC. The effect of 7 days of letrozole pretreatment combined with misoprostol on the expression of progesterone receptor and apoptotic factors of placental and decidual tissues from first-trimester abortion: a randomized controlled trial. Contraception 2016:93(4):323-30.
Cao M, Chan RW, Yeung WS. Label-retaining stromal cells in mouse endometrium awaken for expansion and repair after parturition. Stem Cells Dev. 2015 Mar 15;24(6):768-80. doi: 10.1089/scd.2014.0225. Epub 2014 Dec 22. [PubMed]
Chow JFC, Yeung WSB, Lee VCY, Lau EYL, Ho PC and Ng EHY Experience of more than 100 preimplantation genetic diagnosis cycles for monogenetic diseases using whole genome amplification and linkage analysis in a single centre. Hong Kong Medical Journal 2015, 21(4): 299-303.
Huang VW, Lee CL, Lee YL, Lam KK, Ko JK, Yeung WSB, Ho PC, Chiu PC. Sperm fucosyltransferase-5 mediates spermatozoa-oviductal epithelial cell interaction to protect human spermatozoa from oxidative damage. Molecular Human Reproduction 2015 Jun;21(6):516-26.
Kottawatta KS, So KH, Kodithuwakku SP, Ng EH, Yeung WS, Lee CKF. MicroRNA-212 Regulates the Expression of Olfactomedin 1 and C-Terminal Binding Protein 1 in Human Endometrial Epithelial Cells to Enhance Spheroid Attachment In Vitro. Biol Reprod 2015 Nov;93(5):109.
Lam KW, Li RHW, Ng EHY, Ho PC and Yeung WSB., Semen analysis - what a clinician should know. Journal of Paediatrics, Obstetrics and Gynaecology Singapore 2015, Jan: 37-44.
Lee CL, Guo Y, So KH, Vijayan M, Wong HHV, Yao Y, Lee CKF, Chiu CN and Yeung WSB. Soluble human leukocyte antigen G5 polarizes differentiation of macrophages towards a decidual macrophage-like phenotype. Human Reproduction 2015, 30: 2263-74.
Lee VC, Chow JF, Lau EY, Yeung WS, Ho PC, Ng EH. Comparison between fluorescent in-situ hybridisation and array comparative genomic hybridisation in preimplantation genetic diagnosis in translocation carriers. Hong Kong Med J. 2015 Feb;21(1):16-22. doi: 10.12809/hkmj144222. Epub 2014 Oct 24. [PubMed]
Lee YL, Fong SW, Chen AC, Li T, Yue C, Lee CL, Ng EH, Yeung WS, Lee KF.Establishment of a novel human embryonic stem cell-derived trophoblastic spheroid implantation model. Hum Reprod. 2015 Sep 7. pii: dev223. [Epub ahead of print]
Li HW, Liao SB, Chiu PC, Yeung WS, Ng EH, Cheung AN, Tang F, O WS. Effects of adrenomedullin on the expression of inflammatory cytokines and chemokines in oviducts from women with tubal ectopic pregnancy: an in-vitro experimental study. Reprod Biol Endocrinol. 2015 Nov 5;13(1):120. [Medline]
Li RHW, Lam KSL, Tam S, Lee VCY, Yeung TWY, Cheung PT, Yeung WSB, Ho PC and Ng EHY. Screening for dysglycaemia by oral glucose tolerance test should be recommended in all women with polycystic ovary syndrome. Human Reproduction 2015, 30(9): 2178-2183.
So KH, Kodithuwakku SP, Kottawatta KS, Li RH, Chiu PC, Cheung AN, Ng EH, Yeung WS, Lee KF.Human chorionic gonadotropin stimulates spheroid attachment on fallopian tube epithelial cells through the mitogen-activated protein kinase pathway and down-regulation of olfactomedin-1. Fertil Steril. 2015 May 18. pii: S0015-0282(15)00304-0. doi: 10.1016/j.fertnstert.2015.04.030. [Epub ahead of print]
Wang B, Ye TM, Lee KF, Chiu PC, Pang RT, Ng EH, Yeung WS.Annexin A2 Acts as an Adhesion Molecule on the Endometrial Epithelium during Implantation in Mice. PLoS One. 2015 Oct 7;10(10):e0139506. [Medline]
Ye TM, Pang RT, Leung CO, Chiu JF, Yeung WS. Two-dimensional liquid chromatography with tandem mass spectrometry-based proteomic characterization of endometrial luminal epithelial surface proteins responsible for embryo implantation. Fertil Steril. 2015 Mar;103(3):853-61.e3. doi: 10.1016/j.fertnstert.2014.12.110. Epub 2015 Jan 24. [PubMed]
Chai J, Yeung TWY, Lee VCY, Li RHW, Lau EYL, Yeung WSB, Ho PC and Ng EHY. Live birth rate, multiple pregnancy rate, and obstetric outcomes of elective single and double embryo transfers: Hong Kong experience. Hong Kong Medical Journal 2014, 20(2):102-106.
Cheong AW, Pang RT, Liu WM, Kottawatta KS, Lee KF, Yeung WS. MicroRNA Let-7a and dicer are important in the activation and implantation of delayed implanting mouse embryos. Hum Reprod. 2014 Jan 12. [Epub ahead of print] [PubMed]
Chiu PC, Lam KK, Wong RC, Yeung WS. The identity of zona pellucida receptor on spermatozoa: an unresolved issue in developmental biology. Semin Cell Dev Biol. 2014, 30:86-95.
Chow JF, Yeung WS, Lau EY, Lee VC, Ng EH, Ho PC. Array comparative genomic hybridization analyses of all blastomeres of a cohort of embryos from young IVF patients revealed significant contribution of mitotic errors to embryo mosaicism at the cleavage stage. Reprod Biol Endocrinol. 2014 Nov 24;12:105. doi: 10.1186/1477-7827-12-105. [PubMed]
Chow JF, Yeung WS, Lau EY, Lee VC, Ng EH, Ho PC. Array comparative genomic hybridization analyses of all blastomeres of a cohort of embryos from young IVF patients revealed significant contribution of mitotic errors to embryo mosaicism at the cleavage stage. Reprod Biol Endocrinol. 2014 Nov 24;12:105.
Ko JKY, Huang VW, Li RHW, Yeung WSB, Ho PC and Chiu CN. An in vitro study of the effect of mifepristone and ulipristal acetate on human sperm functions. Andrology 2014;2(6):868-874.
Lee CL, Li K, Lam KK, Ng EH, Koistinen H, Seppälä M, Yeung WS, Chiu PC.Glycodelin-A treatment reduces the adverse effect of macrophage co-culture on human sperm motility. Mol Reprod Dev. 2014 Jun;81(6):482-3. doi: 10.1002/mrd.22331. Epub 2014 May 9. [Medline]
Lee VCY, Chow JFC, Lau EYL, Yeung WSB, Ho PC, Ng EHY. Live birth following double-factor pre-implantation genetic diagnosis for both reciprocal translocation and alpha-thalassaemia. Hong Kong Med J 2014 Jun;20(3):251-4.
Lee VCY, Li RHW, Chai J, Yeung TWY, Yeung WSB, Ho PC and Ng EHY. Effect of preovulatory progesterone elevation and duration of progesterone elevation on the pregnancy rate of frozen–thawed embryo transfer in natural cycles. Fertility and Sterility 2014, 101: 1288-1293.
Leung CO, Deng W, Ye TM, Ngan HYS, Tsao SW, Cheung ANY, Pang RTK and Yeung WSB. miR-135a leads to cervical cancer cell transformation through regulation of β-catenin via a SIAH1-dependent ubiquitin proteosomal pathway. Carcinogenesis 2014 Sep;35(9):1931-40.
Li HW, Liao SB, Yeung WS, Ng EH, O WS, Ho PC. Ulipristal acetate resembles mifepristone in modulating human Fallopian tube function.Hum Reprod. 2014 Aug 19. pii: deu210. [Epub ahead of print]
Li RHW, Lee VCY, Lau EYL, Yeung WSB, Ho PC and Ng EHY. Cumulative live-birth rate in women with polycystic ovary syndrome or isolated polycystic ovaries undergoing in-vitro fertilisation treatment. Journal of Assisted Reproduction and Genetics 2014, 31: 205-211.
Li RHW, Lee VCY, Lau EYL, Yeung WSB, Ho PC and Ng EHY. Role of baseline antral follicle count and anti-Mullerian hormone in the index stimulation cycle of IVF treatment in predicting outcome of subsequent frozen-thawed embryo transfers. Gynecological Endocrinology 2014 30: 490-493.
Li RHW, Lee VCY, Lau EYL, Yeung WSB, Ho PC, Ng EHY. Ovarian response and cumulative live birth rate of women undergoing in-vitro fertilisation who had discordant anti-mullerian hormone and antral follicle count measurements: a retrospective study. PLoS One 014;9(10):e108493.
Li RHW, Liao S., Yeung WSB, Ng EHY, O WS and Ho PC. Ulipristal acetate resembles mifepristone in modulating human Fallopian tube function. Human Reproduction 2014 29: 2156-2162.
Wang Q, Chow JF, Yeung WS, Lau EY, Lee VC, Ng EH, Ho PC. (2014) Preimplantation genetic diagnosis using combined strategies on a breast cancer patient with a novel genomic deletion in BRCA2. Journal of Assisted Reproduction & Genetics 2014;31(12):1719-26
Wu R, Wang ZP, Fung YS, Seah DYP and Yeung WSB. Assessment of adulteration of soybean proteins in dairy products by 2D microchip-CE device Electrophoresis. 2014, 35: 1728-1734.
Xiang L., Chan RWS, Ng EHY and Yeung WSB. Slow-cycling mesenchymal stromal cells in human endometrium possess common hallmark somatic stem cell properties Stem Cell Research & Therapy. 2014, 5: 84.
Chan RW, Mak AS, Yeung WS, Lee KF, Cheung AN, Ngan HY, Wong AS. Human female reproductive tract epithelial cell culture. Methods Mol Biol. 2013;945:347-63. [PubMed]
Guo YF, Lee CL, So KH, Gao J, Yeung WSB, Yao YQ, Lee KF. Soluble Human Leukocyte Antigen-G5 Activates Extracellular Signal-Regulated Protein Kinase Signaling and Stimulates Trophoblast Invasion. PLoS One 2013 Oct 1;8(10):e76023. [PubMed]
Huang VW, Zhao W, Lee CL, Lee CY, Lam KK, Ko JK, Yeung WS, Ho PC, Chiu PC. Cell membrane proteins from oviductal epithelial cell line protect human spermatozoa from oxidative damage. Fertil Steril. 2013 Apr;99(5):1444-1452. [PubMed]
Lee CL, Chiu PC, Hautala L, Salo T, Yeung WS, Stenman UH, Koistinen H. Human chorionic gonadotropin and its free β-subunit stimulate trophoblast invasion independent of LH/hCG receptor. Mol Cell Endocrinol. 2013 Aug 15;375(1-2):43-52. [PubMed]
Lee CL, Lam MPY, Lam KKW, Leung CON, Pang RTK, Chu IK, Wan THL, Chai J, Yeung WSB, Chiu PCN. The identification of CD147 (Basigin) as a mediator of trophoblast functions. Hum Reprod 2013 Sep. [ Epub ahead of print] [PubMed]
Lee VC, Gao J, Lee KF, Ng EH, Yeung WS, Ho PC. The effect of letrozole with misoprostol for medical termination of pregnancy on the expression of steroid receptors in the placenta. Hum Reprod 2013 Nov;28(11):2912-9.[PubMed]
Lee VC, Li RH, Ng EH, Yeung WS, Ho PC. Luteal phase support does not improve the clinical pregnancy rate of natural cycle frozen-thawed embryo transfer: a retrospective analysis. Eur J Obstet Gynecol Reprod Biol. 2013 Jul;169(1):50-3. [PubMed]
Li HW, Lee VC, Lau EY, Yeung WS, Ho PC, Ng EH. Role of baseline antral follicle count and anti-Mullerian hormone in prediction of cumulative live birth in the first in vitro fertilisation cycle: a retrospective cohort analysis. PLoS One. 2013 Apr 23;8(4):e61095. [PubMed]
O WS, Li HWR, Liao SB, Cheung ANY, Ng EHY, Yeung WSB, Ho JC, Tang F. The decreases in adrenomedullin and ciliary beat frequency in the nasal epithelium in tubal pregnancy Fertil Steril (2013 Aug;100(2):459-463 [PubMed]
Pang RT, Leung CO, Lee CL, Lam KK, Ye TM, Chiu PC, Yeung WS. MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1. BMC Cancer. 2013 Jan 18;13:25. doi: 10.1186/1471-2407-13-25. [PubMed]
Tsang H, Cheung TY, Kodithuwakkua SP, Chai J, Yeung WS, Wong CKC, Lee KF. Perfluorooctanoate Suppresses Spheroid Attachment on Endometrial Epithelial Cells Through Peroxisome Proliferator-Activated Receptor Alpha and Down-Regulation of Wnt Signaling. Reprod Toxicol. 2013 Dec;42:164-71. doi: 10.1016/j.reprotox.2013.08.001. Epub 2013 Aug 24. [Medline]
Wong BS, Lam KK, Lee CL, Wong VH, Lam MP, Chu IK, Yeung WS, Chiu PC. Adrenomedullin enhances invasion of human extravillous cytotrophoblast-derived cell lines by regulation of urokinase plasminogen activator expression and s-nitrosylation. Biol Reprod. 2013 Feb 14;88(2):34. [PubMed]
Wu R, Wang Z, Zhao W, Yeung WS, Fung YS. Multi-dimension microchip-capillary electrophoresis device for determination of functional proteins in infant milk formula. J Chromatogr A. 2013 Aug 23;1304C:220-226. [PubMed]
Chen AC, Lee YL, Hou DY, Fong SW, Peng Q, Pang RT, Chiu PC, Ho PC, Lee KF, Yeung WS. Study of transforming growth factor alpha for the maintenance of human embryonic stem cells. Cell Tissue Res. 2012 Nov;350(2):289-303. [Medline]
Chiu CN, Lam KK, Lee CL, Huang VW, Wong BS, Zhao W, Li K, Ho PC, Yeung WSB. Adrenomedullin enhances the progressive motility and zona pellucida-binding capacity of spermatozoa from normozoospermic but not asthenozoospermic men. Molecular Reproduction and Development 2012;79(2): 76. [PubMed]
Gao J, Zuo Y, So KH, Yeung WSB, Ng EHY, Lee KF. Electroacupuncture enhances spermatogenesis in rats after scrotal heat treatment. Spermatogenesis. 2012;2(1):53-62. [Medline]
Kodithuwakku SP, Pang RT, Ng EH, Cheung AN, Horne AW, Ho PC, Yeung WS, Lee KF. Wnt activation downregulates olfactomedin-1 in Fallopian tubal epithelial cells: a microenvironment predisposed to tubal ectopic pregnancy. Lab Invest. 2012;92(2):256-64. [Medline]
Lam KK, Pang RT, Lee CL, Koistinen H, Seppala M, Ho PC, Yeung WS, Chiu PC. Glycodelin-A modulates syncytialization of human BeWo choriocarcinoma cell line. Placenta. 2012 Sep;33(9):750-2 [PubMed]
Lee CL, Lam EY, Lam KK, Koistinen H, Seppälä M, Ng EH, Yeung WS, Chiu PC. Glycodelin-A stimulates interleukin-6 secretion by human monocytes and macrophages through L-selectin and the extracellular signal-regulated kinase pathway. J Biol Chem. 2012 Oct 26;287(44):36999-7009. [PubMed]
Lee VC, Yeung TW, Tang OS, Ng EH, Yeung WS, Ho PC. Effect of letrozole on uterine artery Doppler flow indices prior to first-trimester termination of pregnancy: a randomized controlled trial. Ultrasound Obstet Gynecol. 2012 Oct;40(4):392-7. [PubMed]
Lee YL, Peng Q, Fong SW, Chen AC, Lee KF, Ng EH, Nagy A, Yeung WS. Sirtuin 1 facilitates generation of induced pluripotent stem cells from mouse embryonic fibroblasts through the miR-34a and p53 pathways. PLoS One. 2012;7(9):e45633. [Medline]
Li HW, Ng EH, Wong BP, Anderson RA, Ho PC, Yeung WS. Correlation between three assay systems for anti-Müllerian hormone (AMH) determination. J Assist Reprod Genet. 2012 Dec;29(12):1443-6.
Liao SB, Li HW, Ho JC, Yeung WS, Ng EH, Cheung AN, Tang F, O WS. Possible role of adrenomedullin in the pathogenesis of tubal ectopic pregnancy. J Clin Endocrinol Metab. 2012 Jun;97(6):2105-12. [PubMed]
Liu WM, Pang RT, Cheong AW, Ng EH, Lao K, Lee KF, Yeung WS. Involvement of microRNA lethal-7a in the regulation of embryo implantation in mice. PLoS One. 2012;7(5):e37039. [Medline]
Liu WM, Pang RT, Chiu PC, Wong BP, Lao K, Lee KF, Yeung WS. Sperm-borne microRNA-34c is required for the first cleavage division in mouse. Proc Natl Acad Sci USA. 2012;109(2):490-4. [Medline]
So KH, Lee CL, Yeung WS, Lee KF. Glycodelin suppresses endometrial cell migration and invasion but stimulates spheroid attachment. Reprod Biomed Online. 2012;24(6):639-45. [PubMed]
Tsang H, Cheung TY, Kodithuwakku SP, Chai J, Yeung WS, Wong CK, Lee KF. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) suppresses spheroids attachment on endometrial epithelial cells through the down-regulation of the Wnt-signaling pathway. Reprod Toxicol. 2012 Jan;33(1):60-6. [PubMed]
Ye TM, Pang RT, Leung CO, Liu W, Yeung WS. Development and characterization of an endometrial tissue culture model for study of early implantation events. Fertil Steril. 2012 Dec;98(6):1581-9. [PubMed]
Yeung WSB, Chiu CN. SLeX: potential implications for fertility and contraception. Expert Review of Obstetrics & Gynecology. 2012;7: 1-3.
Chai J, Hon E, Li CF, Pun TC, Yeung WSB, Ho PC. A pilot study of pre-operative misoprostol in reducing operative blood loss during hysterectomy. Eur J Obstet Gynecol Reprod Biol. 2011 Sep;158(1):72-5. [PubMed]
Chai J, Lee KF, Ng EH, Yeung WS, Ho PC. Ovarian stimulation modulates steroid receptor expression and spheroid attachment in peri-implantation endometria: studies on natural and stimulated cycles. Fertil Steril. 2011 Sep;96(3):764-8. [Medline]
Chan RW, Ng EH, Yeung WS. Identification of cells with colony-forming activity, self-renewal capacity, and multipotency in ovarian endometriosis. Am J Pathol. 2011 Jun;178(6):2832-44.14. [PubMed]
Kodithuwakku SP, Ng PY, Liu Y, Ng EHY, Yeung WSB, Ho PC, Lee KF. Hormonal regulation of endometrial olfactomedin expression and its suppressive effect on spheroid attachment onto endometrial epithelial cells. Hum Reprod 2011;26:167-175. [Medline]
Lam KK, Chiu PC, Lee CL, Pang RT, Leung CO, Koistinen H, Seppala M, Ho PC, Yeung WS. Glycodelin-A protein interacts with Siglec-6 protein to suppress trophoblast invasiveness by down-regulating extracellular signal-regulated kinase (ERK)/c-Jun signaling pathway. J Biol Chem. 2011 Oct 28;286(43):37118-27. [PubMed]
Lam MP, Lau E, Siu SO, NgDC, Kong RP, Chiu PC, Yeung WS, Lo C, Chu IK. Online combination of reversed-phase/reversed-phase and porous graphitic carbon liquid chromatography for multicomponent separation of proteomics and glycoproteomics samples. Electrophoresis. 2011 Nov;32(21):2930-40.
Lee CL, Chiu PC, Lam KK, Siu SO, Chu IK, Koistinen R, Koistinen H, Seppälä M, Lee KF, Yeung WS. Differential actions of glycodelin-A on Th-1 and Th-2 cells: a paracrine mechanism that could produce the Th-2 dominant environment during pregnancy. Hum Reprod. 2011 Mar;26(3):517-26. [Medline]
Lee CL, Chiu PC, Pang PC, Chu IK, Lee KF, Koistinen R, Koistinen H, Seppälä M, Morris HR, Tissot B, Panico M, Dell A, Yeung WS. Glycosylation failure extends to glycoproteins in gestational diabetes mellitus: evidence from reduced α2-6 sialylation and impaired immunomodulatory activities of pregnancy-related glycodelin-A. Diabetes. 2011 Mar;60(3):909-17. [Medline]
Lee CL, Lam KK, Koistinen H, Seppala M, Kurpisz M, Fernandez N, Pang RT, Yeung WS, Chiu PC. Glycodelin-A as a paracrine regulator in early pregnancy. J Reprod Immunol. 2011 Jun;90(1):29-34.
Lee VC, Chan CC, Ng EH, Yeung WS, Ho PC. Sequential use of letrozole and gonadotrophin in women with poor ovarian reserve: a randomized controlled trial. Reprod Biomed Online. 2011 Sep;23(3):380-8.
Lee VC, Ng EH, Yeung WS, Ho PC. Misoprostol with or without letrozole pretreatment for termination of pregnancy: a randomized controlled trial. Obstet Gynecol. 2011 Feb;117(2 Pt 1):317-23 [PubMed]
Lee VC, Tang OS, Ng EH, Yeung WS, Ho PC. A pilot study on the use of letrozole with either misoprostol or mifepristone for termination of pregnancy up to 63 days. Contraception. 2011 Jan;83(1):62-7.
Lee VC, Tang OS, Ng EH, Yeung WS, Ho PC. A prospective double-blinded, randomized, placebo-controlled trial on the use of letrozole pretreatment with misoprostol for second-trimester medical abortion. Contraception. 2011 Dec;84(6):628-33.
Li HWR, Yeung WSB, Lau EY, Ho PC, Ng EHY. Evaluating the performance of serum antimullerian hormone concentration in predicting the live birth rate of controlled ovarian stimulation and intrauterine insemination. Fertil Steril. 2010;94:2177-81. [PubMed]
Li RHW, Anderson RA, Yeung WS, Ho PC, Ng EH. Evaluation of serum antimullerian hormone and inhibin B concentrations in the differential diagnosis of secondary oligoamenorrhea. Fertil Steril. 2011 Sep;96(3):774-9. [PubMed]
Li RHW, Wong GCY, Yeung WSB, Ho PC, Ng EHY. Serum anti-mullerian hormone level is not altered in women using hormonal contraceptives. Contraception 2011;83:582-585.
Pang PC, Chiu PC, Lee CL, Chang LY, Panico M, Morris HR, Haslam SM, Khoo KH, Clark GF, Yeung WS, Dell A. Human sperm binding is mediated by the sialyl-Lewis(x) oligosaccharide on the zona pellucida. Science. 2011 Sep 23;333(6050):1761-4. [PubMed]
Pang RT, Liu WM, Leung CO, Ye TM, Kwan PC, Lee KF, Yeung WS. miR-135A regulates preimplantation embryo development through down-regulation of E3 Ubiquitin Ligase Seven In Absentia Homolog 1A (SIAH1A) expression. PLoS One. 2011;6:e27878. [Medline]
Wan HT, Zhao Y, Wong M, Lee KF, Yeung WS, Giesy JP, Wong CK. Testicular Signaling Is the Potential Target of Perfluorooctanesulfonate-Mediated Subfertility in Male Mice. Biol Reprod. 2011 May;84(5):1016-23. [Medline]
Wei X, Lee KF, Yeung WSB, Giesy JP, Wong MH, Wong CK. Effect of perinatal and postnatal bisphenol A exposure to the regulatory circuits at the hypothalamus-pituitary-gonadal axis of CD-1 mice. Reprod Toxicol. 2011 May;31(4):409-17. [Medline]
Chiu CN, Liao S, Lam KW, Tang F, Ho JCM, Ho PC, O WS, Yao QY, Yeung WSB. Adrenomedullin regulates sperm motility and oviductal ciliary beat via cyclic adenosine 5'-monophosphate/protein kinase A and nitric oxide, Endocrinology. 2010;151:3336-3347. [PubMed]
Chiu PC, Wong BS, Lee CL, Lam KK, Chung MK, Lee KF, Koistinen R, Koistinen H, Gupta SK, Seppälä M, Yeung WS. Zona pellucida-induced acrosome reaction in human spermatozoa is potentiated by glycodelin-A via down-regulation of extracellular signal-regulated kinases and up-regulation of zona pellucida-induced calcium influx. Hum Reprod 2010;25:2721-33.
Lam MP, Siu SO, Lau E, Mao X, Sun HZ, Chiu PC, Yeung WS, Cox DM, Chu IK. Online coupling of reverse-phase and hydrophilic interaction liquid chromatography for protein and glycoprotein characterization. Anal Bioanal Chem. 2010 Sep;398(2):791-804. Epub 2010 Jul 15.
Lee CL, Chiu CN, Lam KW, Chan RWS, Chu IK, Koistinen R, Koistinen H, Seppala M, Lee KF, Yeung WSB. Glycodelin-A modulates cytokine production of peripheral blood natural killer cells. Fertil Steril 2010;94:769-71. (Publication No. : 177299)
Lee KF, Lee YL, Chan RWS, Cheong AWY, Ng EHY, Ho PC, Yeung WSB. Up-regulation of endocrine gland-derived vascular endothelial growth factor but not vascular endothelial growth factor in human ectopic endometriotic tissue, Fertility and Sterility. 2010;93:1052-1060. (Publication No. : 175168)
Lee VCY, Ng EHY, Yeung WSB, Ho PC. Impact of positive hepatitis B surface antigen on the outcome of IVF treatment. Reprod Biomed Online 2010;21:712-7.
Li HWR, Hui PW, Tang MHY, Lau ET, Yeung WSB, Ho PC, Ng EHY. Maternal serum anti-Mullerian hormone level is not superior to chronological age in predicting Down syndrome pregnancies. Prenat Diagn. 2010;30:320-4.
Li HWR, Liao S, Chiu PCN, Tam WW, Ho JCM, Ng EHY, Ho PC, Yeung WSB, Tang F, O WS, Expression of adrenomedullin in human oviduct, its regulaton by the hormonal cycle and contact with spermatozoa, and its effect on ciliary beat frequency of the oviductal epithelium, Journal of Clinical Endocrinology and Metabolism. 2010;95:E18-E25. (Publication No. : 182871)
Liu Y, Kodithuwakku SP, Ng PY, Chai J, Ng EH, Yeung WS, Ho PC, Lee KF. Excessive ovarian stimulation up-regulates the Wnt-signaling molecule DKK1 in human endometrium and may affect implantation: an in vitro co-culture study. Hum Reprod 2010;25:479-90. [PubMed]
Pang RTK, Leung ON, Ye T, Liu W, Chiu CN, Lam KW, Lee KF, Yeung WSB. MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells, Carcinogenesis 2010;31:1037-1044. [PubMed]
Siu SO, Lam MP, Lau E, Yeung WS, Cox DM, Chu IK. N-linked glycoprotein analysis using dual-extraction ultrahigh-performance liquid chromatography and electrospray tandem mass spectrometry. Methods Mol Biol. 2010;600:133-43.
So WS, Ng EHY, YY Wong, EYL Lau, WSB Yeung, Ho PC. Acupuncture for frozen-thawed embryo transfer cycles: a double-blind randomized controlled trial. Reproductive BioMedicine Online 2010;20,814-821.
Yeung WS, Li RH, Cheung TM, Ng EH, Lau EY, Ho PC. Frozen-thawed embryo transfer cycles. Hong Kong Med J. 2009;15:420-6.
Yeung WSB, Lee YL, Lee KF. Coculture and Assisted Reproduction, In: WL Ledger, SL Tan and AOS Bahathiq, The Fallopian tube in fertility and IVF practice. Cambridge University Press, 2010, 8-17. (Publication No. : 174169)
Zuo Y, Gao J, Yeung WS, Lee KF. The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence. Biochem Biophys Res Commun. 2010;401:275-80.
Lam KK, Chiu PC, Chung MK, Lee CL, Lee KF, Koistinen R, Koistinen H, Seppala M, Ho PC, Yeung WS. Glycodelin-A as a modulator of trophoblast invasion. Hum Reprod. 2009 Sep;24(9):2093-103. [PubMed]
Lee CL, Pang PC, Yeung WS, Tissot B, Panico M, Lao TT, Chu IK, Lee KF, Chung MK, Lam KK, Koistinen R, Koistinen H, Seppälä M, Morris HR, Dell A, Chiu PC. Effects of differential glycosylation of glycodelins on lymphocyte survival. J Biol Chem. 2009 May 29;284(22):15084-96. [PubMed]
Chiu PC, Wong BS, Lee CL, Pang RT, Lee KF, Sumitro SB, Gupta SK, Yeung WS. Native human zona pellucida glycoproteins: purification and binding properties. Hum Reprod. 2008 Jun;23(6):1385-93. [PubMed]
Lee YL, Liu Y, Ng PY, Lee KF, Au CL, Ng EH, Ho PC, Yeung WS. Aberrant expression of angiopoietins-1 and -2 and vascular endothelial growth factor-A in peri-implantation endometrium after gonadotrophin stimulation. Hum Reprod. 2008 Apr;23(4):894-903. [PubMed]
Liu Y, Lee KF, Ng EH, Yeung WS, Ho PC. Gene expression profiling of human peri-implantation endometria between natural and stimulated cycles. Fertil Steril. 2008 Dec;90(6):2152-64. doi: 10.1016/j.fertnstert.2007.10.020. Epub 2008 Jan 14. [PubMed]
Chiu PC, Chung MK, Koistinen R, Koistinen H, Seppala M, Ho PC, Ng EH, Lee KF, Yeung WS. Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding. J Cell Sci. 2007 Jan 1;120(Pt 1):33-44. [PubMed]
Chiu PC, Tsang HY, Koistinen R, Koistinen H, Seppala M, Lee KF, Yeung WS. (2004) The contribution of D-mannose, L-fucose, N-acetylglucosamine, and selectin residues on the binding of glycodelin isoforms to human spermatozoa. Biol Reprod. 70, 1710-9.
Hong SJ, Chiu PC, Lee KF, Tse JM, Ho PC, Yeung WS. (2004) Establishment of a capillary-cumulus model to study the selection of sperm for fertilization by the cumulus oophorus. Hum Reprod. 19, 1562-9.
Lee KF, Yeung WS, Chow JF, Shum CK, Luk JM. (2004) Different testicular gene expression patterns in the first spermatogenic cycle of postnatal and vitamin A-deficient rat testis. Biol Reprod. 70, 1010-7.
Lee YL, Lee KF, Xu JS, He QY, Chiu JF, Lee WM, Luk JM, Yeung WS. (2004) The embryotrophic activity of oviductal cell-derived complement C3b and iC3b, a novel function of complement protein in reproduction. J Biol Chem. 279, 12763-8.
- MicroRNA-135a transforms normal HPV infected cervical cells into cancer cells and cells with cancer stem cell-like properties (HK$848,712) (2013)
- Role of microRNA let-7 in implantation of mouse blastocysts (HK$1,032,012, HKU 783910M) (2010)
- Control of human trophoblast invasion by glycodelin-A. (HK$ 804,125, HKU763508M) (2009)
- Characterization of stem/progenitor cells in human Endometriosis. GRF (HK$ 944,700, HKU782209M) (2009)
- Combined use of letrozole and misoprostol for medical termination of pregnancy. (HK$ 747,696, GRF 765508) (2009)
- A study on glycodelin-A induced differentiation of trophoblast cells. (HK$ 649,765, GRF 780308) (2009)
- Adrenomedullin and sperm functions (HK$ 654,500, HKU 7578/06M (2006-2008)
- Biomedical nanoparticle analysis system based on hyphenating gasphase electrophoretic mobility molecular sizer with nanometer aerosol sampler and elemental analyzers for morphological and chemical analysis of mitochondria from mouse oocyte. (HK$ 557,500, HKU702307P) (2007)
- Functional characterization of a testis-specific Trs4 gene on spermatogenesis by tissue-specific conditional inactivation (HK$730,700, N_HKU 712/06) (2007-2010)
- Stem cell related genes in gestational trophoblastic diseases. (HK$ 939,968) (2005-2006)
- Role of olfactomedin in implantation. (HK$ 1,109,957) (2006-2008)
- Functional characterization of VAD1.3, a novel acrosome-specific protein by conditional tissue-specific gene inactivation (HK$ 884,957) (2006-2008)
- The mechanism of action of a novel glycodelin isoform from cumulus matrix on stimulating spermatozoa-zona pellucida binding (HK$1,279,500, HKU 7647/06M (2006-2009)
- Hong Kong Society of Endocrinology, Metabolism and Reproduction (since 1985)
- Society for the Study of Fertility, United Kingdom (since 1988)
- American Society for Reproductive Medicine (since 1991)
- European Society for Human Reproduction and Embryology (sinc3 1993)
Alpha, an international society for embryologist (since 1995)
Awards and Honors
- Faculty of 1000 “Naturally Selected” on December 2011: Human sperm binding is mediated by the sialyl-Lewis(x) oligosaccharide on the zona pellucida. Science. 2011;333(6050):1761-4.: Faculty of 1000